General Information

  • ID:  hor003340
  • Uniprot ID:  A0A903UAT1
  • Protein name:  Orcokinin-1
  • Gene name:  5569132
  • Organism:  Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
  • Family:  Orcokinin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Stegomyia (subgenus), Aedes (genus), Aedini (tribe), Culicinae (subfamily), Culicidae (family), Culicoidea (superfamily), Culicomorpha (infraorder), Nematocera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  NFDEIDRYSTFG
  • Length:  12
  • Propeptide:  MFKLHVICAIFLFALLSWSNAQPVKDQEVEDLIYKLQQLKQLNDASQIAPTDPHSSGGGEKERSHLAPDPSTGSLKTKRSLNNSDRRTLLYQYYARGLAPMYDKRNFDEIDRYSTFGGKRNYEFMTPQERHSTIKRNFDEIDQWAGFNSRLRPSMSGYGKRNFDEIDRYGKFNKRLFREVEDLGAISPNSLKQHGSNLADEMAVINEYAQ
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Myotropic
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor003340_AF2.pdbhor003340_ESM.pdb

Physical Information

Mass: 165990 Formula: C65H90N16O23
Absent amino acids: ACHKLMPQVW Common amino acids: DF
pI: 3.88 Basic residues: 1
Polar residues: 5 Hydrophobic residues: 3
Hydrophobicity: -96.67 Boman Index: -4010
Half-Life: 1.4 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 32.5
Instability Index: 2069.17 Extinction Coefficient cystines: 1490
Absorbance 280nm: 135.45

Literature

  • PubMed ID:  20163154
  • Title:  Neuropeptidomics of the Mosquito Aedes Aegypti